USA´S Top 10 Busiest Domestic Airline Routes

Hartsfield–Jackson Atlanta International Airport (ATL) in the US consistently ranks as the nation’s busiest airport. Flights from this airport also feature on this list of the busiest domestic airline route. Some of the most punctual airlines in the US also serve along these routes. Also serving these routes are some of the busiest US airlines (by seats) for February 2025. Let’s have a look at the ten busiest domestic airline routes in the US for February 2025.

[ Note: The rankings were based on the data from OAG, a global air traffic data provider. The data was available when the writer last checked the website on 15th February.]

10.EWR – MCO

Newark Liberty International Airport (EWR)
Image: qwesy qwesy | Wikimedia Commons

Route	Newark Liberty International Airport (EWR) – Orlando International Airport (MCO)
Seats Capacity	198,062
Distance	1,510 km

PT-MSZ at MCO
Image: elisfkc | Wikimedia Commons

Non-stop flight operated from EWR to MCO:

Airline	Approximate time taken	Aircraft Used
JetBlue Airways	2h 56m	Airbus A320
United Airlines	2h 56m	Boeing 700-900 Passenger
Spirit Airlines	3h 01m	A321neo

Delta Boeing 737-800
Image:Greg Goebel | Wikimedia Commons

One-stop flights operated from EWR to MCO:

Airline	Stopover at	Approximate Flight time	Aircraft Used
Delta Air Lines	Raleigh/Durham (RUD)	4h 36m	Canadair Regional Jet 900
United Airlines	Dulles (IAD)	5h 05m	Boeing 737-800 Passenger
American Airlines	Charlotte (CLT)	5h 12m	Airbus A321
American Airlines	Miami (MIA)	5h 32m	Boeing 737MAX 8
Delta Air Lines	Atlanta (ATL)	5h 46m	Boeing 757
Spirit Airlines	Atlanta (ATL)	5h 35m	Airbus A321 (sharklets)

9. ATL – FLL

Hartsfield-Jackson Atlanta International Airport
Image: DiscoA340 | Wikimedia Commons

Route	Hartsfield-Jackson Atlanta International Airport (ATL) – Fort Lauderdale-Hollywood International Airport (MCO)
Seats Capacity	209,908
Distance	936 km

FLL airport
Image: Maarten Visse | Wikimedia Commons

Non-stop flight operated from ATL – FLL :

Airline	Approximate time taken	Aircraft Used
Delta Air Lines	1h 53m	Boeing 757 Passenger
Southwest Airlines	1h 55m	Boeing 737-800 (winglets)
Spirit Airlines	1h 54m	Airbus A320 (sharklets)
Frontier Airlines	2h 01m	A321neo

An Airbus A321neo operated by Frontier
Image: Andrew Heneen | Wikimedia Commons

One-stop flights operated from ATL – FLL :

Airline	Stopover at	Approximate Flight time	Aircraft Used
Delta Air Lines	Raleigh/Durham(RUD)	5h 13m	Canadair Regional Jet 900
Southwest Airlines	Tampa (TPA)	3h 35m	Boeing 737-800 Passenger
American Airlines	Charlotte (CLT)	4h 41m	Airbus A321
Southwest Airlines	New Orleans (MSY)	5h 10m	Boeing 737MAX 8
Spirit Airlines	Orlando (MCO)	4h 51m	Boeing 757
Spirit Airlines	New Orleans (MSY)	5h 03m	Airbus A321 (sharklets)

8.DEN – LAS

Denver international airport
Image: Jacob Montgomery | Wikimedia Commons

Route	Denver International Airport (DEN) – Harry Reid International Airport (LAS)
Seats Capacity	213,783
Distance	1,011 km

Harry Reid International Airport (LAS)
Image:Noah Wulf | Wikimedia Commons

Non-stop flights operated from DEN – LAS :

Airline	Approximate time taken	Aircraft Used
Southwest Airlines	2h 00m	Boeing 737MAX 8 Passenger
United Airlines	2h 4m	Boeing 737-800 Passenger
Frontier Airlines	2h 09m	A321neo

Southwest Airlines 737 N48IWN Denver International Airport
Image: Hurstbergn | Wikimedia Commons

One-stop flights from DEN – LAS :

Airline	Stopover at	Approximate Flight time	Aircraft Used
Delta Air Lines	Salt Lake City (SLC)	4h 40m	Airbus A 220-300
Southwest Airlines	Albuquerque (ABQ)	3h 35m	Boeing 737MAX 8 Passenger
American Airlines	Phoenix (PHX)	4h 41m	Boeing 737-700 (winglets) Passenger/BBJ1
Southwest Airlines	Ontario (ONT)	5h 00m	Boeing 737MAX 8
Frontier Airlines	Salt Lake City(SLC)	5h 09m	Airbus A320neo
American Airlines	Los Angeles (LAX)	6h 23m	Boeing 737-800 Passenger

7.LGA – ORD

American Airlines 737 landing at LaGuardia Airport
Image:Headphase | Wikimedia Commons

Route	LaGuardia Airport (LGA) – O´Hare International Airport(ORD)
Seats Capacity	218,204
Distance	1,177 km

American Airlines planes at the Chicago O’Hare International Airport (ORD)
Image:Matthew T Rader | Wikimedia Commons

Non-stop flights operated from LGA – ORD :

Airline	Approximate time taken	Aircraft Used
Spirit Airlines	2h 38m	Airbus A320 (sharklets)
United Airlines	2h 40m	Airbus A319
American Airlines	2h 40m	Airbus A319
Delta Air Lines	2h 44m	Embraer 175

Delta Air Line at ORD
Image: Aero Icarus | Wikimedia Commons

One-stop flights operated from LGA – ORD:

Airline	Stopover at	Approximate Flight time	Aircraft Used
Delta Air Lines	Detroit (DTW)	4h 40m	Boeing 717-200
Southwest Airlines	Nashville (BNA)	5h 50m	Boeing 737MAX 8 Passenger
American Airlines	Port Columbus (CMH)	5h 10m	Embraer 175
Spirit Airlines	Detroit (DTW)	4h 07m	Boeing 737MAX 8
United Airlines	Washington (IAD)	5h 00m	Boeing 737-800
American Airlines	Cleveland (CLE)	4h 48m	Embraer 175

6.JFK – LAX

John F. Kennedy International Airport
Image:w_lemay | Wikimedia Commons

Route	John F.Kennedy International Airport (JFK) – Los Angeles International Airport(LAX)
Seats Capacity	229,067
Distance	3,974 km

Non-stop flights operated from JFK – LAX:

Airline	Approximate time taken	Aircraft Used
Delta Air Lines	6h 27m	Boeing 767-400
JetBlue Airlines	6h 19m	Airbus A318
American Airlines	6h 25m	Airbus A321

JetBlue A320-200 arriving at LAX
Image:Tim | Wikimedia Commons

One-stop flights operate from JFK – LAX:

Airline	Stopover at	Approximate Flight time	Aircraft Used
Delta Air Lines	Washington (DCA)	8h 14m	Boeing 717-200
Alaska Airlines	San Francisco (SFO)	11h 30m	Boeing 737-900
American Airlines	Charlotte (CLT)	9h 02m	Boeing 737-800
JetBlue Airways	Boston (BOS)	9h 40m	Airbus A 220-300
Delta Air Lines	Atlanta (ATL)	9h 16m	Boeing 737-800
American Airlines	Austin(AUS)	10h 55m	Boeing 737-800 Passenger

5.LAX – SFO

Los Angeles International Airport
Image:Simply Aviation | Wikimedia Commons

Route	Los Angeles International Airport(LAX) – San Francisco International Airport (SFO)
Seats Capacity	257,118
Distance	543.19 km

A United Boeing 777-300ER at San Francisco International Airport
Image:4300streetcar | wikimedia Commons

Non-stop flights operated from LAX – SFO:

Airline	Approximate time taken	Aircraft Used
Delta Air Lines	1h 25m	Airbus A320
United Airlines	1h 32m	Boeing 737-900 Passenger
American Airlines	1h 28m	Boeing 737-800
Frontier Airlines	1h 36m	Airbus A320neo
Southwest Airlines	1h 25m	Boeing 737-700

Southwest airline
Image:Luiz Eduardo | Wikimedia Commons

One-stop flights operated from LAX – SFO:

Airline	Stopover ar	Approximate Flight Time	Aircraft Used
Southwest Airlines	Mc Carran (LAS)	3h 55m	Boeing 737-800
United Airlines	Mc Carran (LAS)	5h 51m	Boeing 737-900
Alaska Airlines	Mc Carran (LAS)	4h 44m	Boeing 737-800

4.HNL – OGG

Japan Airlines Boeing 747-400s and Qantas Boeing 767-300 at HNL
Image: Ajtnk | Wikimedia Commons

Route	Daniel K.Inouye International Airport (HNL) – Kahului Airport(OGG)
Seats Capacity	257,160
Distance	161 km

Hawaiian Airlines Boeing 717-200 at Kahului Airport (OGG)
Image: FRED | Wikimedia Commons

Non-stop flights operated from HNL – OGG:

Airline	Approximate time taken	Aircraft Used
Hawaiian Airlines	0h 41m	Boeing 717-200
Southwest Airlines	0h 50m	Boeing 737MAX 8 Passenger

Southwest Airlines Airplane at Honolulu International Airport
Image: Mds08011 | Wikimedia Commons

One-stop flights from HNL – OGG:

Airline	Stopper at	Approximate Flight time	Aircraft Used
Southern Airways Express	Hoolehua (MKK)	2h 50m	Cessna (Light aircraft-single turboprop engine)
Southern Airways Express	Lanai (LNY)	3h 02m	Cessna (Light aircraft-single turboprop engine)

3.ATL – MCO

ATL AIRPORT
Image: Eric Salard | Wikimedia Commons

Route	Hartsfield-Jackson Atlanta International Airport (ATL) – Fort Lauderdale-Hollywood International Airport (MCO)
Seats Capacity	258,846
Distance	650.74 km

An Azul Airlines jet at Gate 243 (Terminal C) at MCO
Image: Pokemonprime | Wikimedia Commons

Non-stop flights operated from ATL – MCO:

Airline	Approximate time taken	Aircraft Used
Spirit Airlines	1h 32m	Airbus A320
Southwest Airlines	1h 30m	Boeing 737-700
Frontier Airlines	1h 41m	Airbus A321
Delta Air Lines	1h 33m	Boeing 757 Passenger

MCO Airport
Image: inazakira | Wikimedia Commons

One-stop flights operated from ANT – MCO:

Airline	Stopover ar	Approximate Flight Time	Aircraft Used
Delta Air Lines	Pensacola ( PNS)	4h 20m	Boeing 737-800
American Airlines	Miami (MIA)	4h 51m	Boeing 737-900
Delta Airlines	Charlotte (CLT)	4h 44m	Boeing 737-800

2.DEN – PHX

American Airlines at DEN airport
Image:Wikimedia Commons

Route	Denver International Airport (DEN) – Phoenix Sky Harbor International Airport(PHX)
Seats Capacity	264,695
Distance	969 km

USAirways A319-132 at PHX
Image:Moody 75 | Wikimedia Commons

Airline	Approximate time taken	Aircraft Used
Southwest Airlines	2h 00m	Boeing 737MAX 8 Passenger
United Airlines	2h 4m	Boeing 737-800 Passenger
Frontier Airlines	2h 09m	A321neo
American Airlines	2h 03m	Boeing 737-800 Passenger

United Airlines Boeing 767-424 ER
Image: Anna Zvereva | Wikimedia Commons

One-stop flights operated from DEN – PHX:

Airline	Stopper at	Approximate Flight time	Aircraft Used
Delta Air Lines	Salt Lake City (SLC)	3h 10m	Airbus A 22-300
Key Lime Air	Telluride(TEX)	3h 10m	Boeing 737-900
Southwest Airlines	Colorado (COS)	4h 20m	Boeing 737MAX 8 Passenger
Frontier Airlines	Mc Carran(LAS)	5h 09m	Airbus A320neo

1.LAS – LAX

Alaska Airlines Boeing 737-990 at Honolulu Airport
Photo: Tony Hisgett|Wikimedia Commons

Route	Harry Reid International Airport (LAS) – Los Angeles International Airport(LAX)
Seats Capacity	265,508
Distance	380 km

United Airlines Arriving at LAX form DEN airport
Photo: Wikimedia Commons

Airline	Approximate time taken	Aircraft Used
Delta Air Lines	1h 18m	Boeing 737-800 Passenger
United Airlines	1h 17m	Boeing 737-900 Passenger
American Airlines	1h 19m	Boeing 737-800 Passenger
Frontier Airlines	1h 20m	Airbus A320neo
Spirit Airlines	1h 21m	Airbus A320
Alaska Airlines	1h 20m	Embraer 175

Airline	Stopper at	Approximate Flight time	Aircraft Used
Delta Air Lines	San Diego(SAN)	3h 31m	Embraer 175 (Enhanced Winglets)
United Airlines	San Diego(SAN)	3h 31m	Embraer 175